Dual antiplatelet therapy of patients with acute myocardial infarction after coronary artery stenting

Objective: to study the effectiveness of dual antiplatelet therapy (DAPT) in patients with myocardial infarction (MI) after emergency percutaneous coronary intervention (PCI).Material and methods. The involved 20 who underwent PCI at Department Interventional Cardiology Khust district hospital, Zakarpattia region. After artery stenting during 12 months addition complex (Metoprolol, Rosuvastatin, Ramipril, Pantoprazole) received acetylsalicylic acid Ticagrelor (Brilinta). A clinical course disease was analyzed. Prothrombin time, prothrombin index, international normalized ratio (INR), activity liver transaminases, total bilirubin concentration blood serum were determined. Results. During period for acute transmural MI stenting, re-admissions exacerbation underlying not registered. One patient developed a side effect DAPT form mild gastrointestinal bleeding. DAPT, reliable increase time from 12,77±0,18 sec. 13,45±0,34 (р<0,05) (INR) 0,95±0,008 Un 1,0±0,026 (р<0,05). Inconsiderable but alanine aminotransferase (ALT) 14,4±1,11 Un/L 16,67±1,25 found (р<0,05).Conclusions1. Patients (PCI) are well tolerant Ticagrelor. For registered.2. Increase values is indicative decrease coagulation activity.